Guideline on Ovarian Stimulation for IVF/ICSI

Topics covered in this guideline:

  • Ovarian response testing

  • Ovarian stimulation protocols

  • Criteria for triggering ovulation

  • Criteria for cycle cancellation

  • Prevention of ovarian hyperstimulation syndrome (OHSS)

What are some gaps in ovarian stimulation for IVF/ICSI based on current literatures?

  • Gonadotropin dose reduction in predicted high responders as a tool for normalization of ovarian response (GnRH agonist or antagonist) compared to a standard dosage with option GnRH agonist trigger and/or a freeze-all strategy (in GnRH antagonist protocol).

  • Pre-treatment options for scheduling in GnRH antagonist protocol compared to GnRH agonist protocol

  • GnRH agonist LPS compared to progesterone LPS compared to low dose hCG LPS

  • The efficacy and safety of a freeze-all strategy in cycles with routine embryo biopsy for PGD of PGS

  • GnRH agonist trigger with adjusted luteal support compared to 10.000 hCG trigger with freeze all in observed high responders

Last Reviewed: September 21, 2023