Prevention and Treatment of Moderate and Severe OHSS Guideline

Below are some topics covered in this guideline:

• Pathophysiology of OHSS

• Summary statements on pharmacologic therapies (e.g., GnRH antagonist, metformin) to reduce the risk of OHSS

• Role of cryopreservation and OHSS

• List of recommended OHSS management options and evidence behind them

What are some gaps in OHSS prevention and treatment based on this guideline?

• Assess the efficacy of coasting (withholding gonadotrophins) for reduction of OHSS in larger population

• The use of cabergoline to prevent OHSS when using a Lupron trigger

• Best practices for prevention of OHSS in the oncofertility population.

Last Reviewed: September 21, 2023