Guideline for Recurrent Pregnancy Loss (RPL)

Some topics covered by this guideline:

• Risk factors for RPL

• Screening for factors (e.g., genetic, thrombophilia, immunologic) associated with RPL

• Prognosis and treatment options for RPL

What are some gaps in RPL based on current literature?

• Optimal endometrial characteristics for pregnancy; develop tests that detect women with sub-optimal endometrium and treatments to improve it.

• The mechanisms of sperm DNA damage and RPL

• Increase treatment options for factors associated with RPL to increase pregnancy and live birth rates

Last Reviewed: September 21, 2023